MIRA-1野生型p53构象/细胞功能的恢复剂
Restores wild-type conformation, function and DNA binding activity to mutant p53. Induces p53 transcriptional transactivation of p21, MDM2 and PUMA, and promotes tumor cell death by apoptosis in a mutant p53-dependent manner in vitro (IC50 = 10μM).
货号：ajci10028
CAS：72835-26-8
分子式：C8H9NO4
分子量：183.16
纯度：＞99%
溶解：18.3mg/mL in ethanol, or in DMSO
存储：Store at -20°C
库存：现货
| 包装（需要更多包装请咨询） | 价格（￥） | 纯度 | 库存 | 购买 |
|---|---|---|---|---|
| 10mg | 550 | ＞98% | 现货 | 购买点击此链接 |
| 50mg | 850 | ＞98% | 现货 | |
| 100mg | 1300 | ＞98% | 现货 | |
| 250mg | 1800 | ＞98% | 现货 |
MIRA-1 is a maleimide-derived small molecule that reactivates the tumor suppressor function of mutant p53, inducing apoptosis in several human solid tumor cell lines carrying tetracycline-regulated mutant p53 (IC50 = 10 μM in vitro).1 Treatment of tumor cells with MIRA-1 induces p21, MDM2 and PUMA in a mutant p53-dependent manner.[1] At a concentration of 5-10 mg/kg, MIRA-1, alone or in combination with dexamethasone , arrested tumor growth in a mouse xenograft model of multiple myeloma.[2]
我司MIRA-1产品核磁分析如下：
参考文献:
[1]. Bykov, V.J.N., Issaeva, N., Zache, N., et al. Reactivation of mutant p53 and induction of apoptosis in human tumor cells by maleimide analogs. The Journal of Biological Chemisty 280(34), 30384-30391 (2005).
[2]. Saha, M.N., Chen, Y., Chen, M.H., et al. Small molecule MIRA-1 induces in vitro and in vivo anti-myeloma activity and synergizes with current anti-myeloma agents. British Journal of Cancer 110(9), 2224-2231 (2014).
