A-RAF

英文解释

A-Raf is one of the members of the Raf family, possess a Ras-binding domain (RBD) in their N-terminal regulatory region and can function as effectors of active GTP-bound. A-Raf can be activated by the human oncogene RAS family, downstream from which exerts both kinase-dependent and kinase-independent, tumor-promoting functions.

中文解释

A-Raf 是 Raf family 的成员之一，在其 N 末端调节区具有 结合结构域 (RBD)，可作为活性 GTP 结合 的效应子发挥作用。A-Raf 可被人类致癌基因 RAS family 激活，其下游发挥激酶依赖性和非激酶依赖性的肿瘤促进功能。

参考文献

[1]. David E Durrant, et al. Targeting the Raf kinases in human cancer: the Raf dimer dilemma. Br J Cancer. 2018 Jan;118(1):3-8.