Acetyl CoA (acetyl coenzyme A)

乙酰辅酶 A

英文解释

Acetyl CoA (acetyl coenzyme A) is a central metabolic intermediate. The abundance of acetyl-CoA in distinct subcellular compartments reflects the general energetic state of the cell. Moreover, acetyl-CoA concentrations influence the activity or specificity of multiple enzymes, either in an allosteric manner or by altering substrate availability. Finally, by influencing the acetylation profile of several proteins, including histones, acetyl-CoA controls key cellular processes, including energy metabolism, mitosis, and autophagy, both directly and via the epigenetic regulation of gene expression.

中文解释

乙酰辅酶 A (acetyl coenzyme A) 是一种中枢代谢中间体。在不同的亚细胞隔间中乙酰辅酶A的丰富程度反映了细胞的一般能量状态。此外，乙酰辅酶 A 浓度影响多种酶的活性或特异性，无论是通过变构的方式，还是通过改变底物的可用性。最后，通过影响包括组蛋白在内的几种蛋白质的乙酰化谱，乙酰辅酶 A 控制着关键的细胞过程，包括能量代谢、有丝分裂和自噬，直接和通过基因表达的表观遗传学调控。

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