antibody-dependent cellular cytotoxicity (ADCC)

抗体依赖性细胞介导的细胞毒性

英文解释

Antibody-dependent cell-mediated cytotoxicity (ADCC) refers to the direct killing of target cells by lethal cells such as Natural killer cells (NKs), which recognize the Fc segment of antibody coated on target antigen through Fc receptors (FcRs) expressed by NK cells.

中文解释

抗体依赖性细胞介导的细胞毒性 (ADCC)，指具有杀伤性的细胞如 NK 细胞 Natural killer cells (NKs) 通过其表达的 Fc 受体 Fc receptors (FcRs) 识别包被于靶抗原上的抗体 Fc 段，直接杀死靶细胞。

参考文献

[1]. Luqman M, et al. The antileukemia activity of a human anti-CD40 antagonist antibody, HCD122, on human chronic lymphocytic leukemia cells. Blood. 2008 Aug 1;112(3):711-20.