Apurinic endonuclease 1 (APE1)

无嘌呤核酸内切酶 1

英文解释

Apurinic endonuclease 1 (APE1) is one of the key enzyme in the DNA base excision repair system. APE1 hydrolyzes DNA adjacent to the 5'-end of an apurinic/apyrimidinic (AP) site to produce a nick with a 3'-hydroxyl group and a 5'-deoxyribose phosphate moiety.

中文解释

无嘌呤核酸内切酶 1 (APE1) 是 DNA 碱基切除修复系统中的关键酶之一。APE1 可水解与无嘌呤/无嘧啶 (AP) 位点的 5'-末端相邻的 DNA，以产生具有 3'-羟基和 5'-脱氧核糖磷酸部分的切口。

参考文献

[1]. Dyrkheeva NS, et al. AP Endonuclease 1 as a Key Enzyme in Repair of Apurinic/Apyrimidinic Sites. Biochemistry (Mosc). 2016 Sep;81(9):951-67.