Aromatase

芳香化酶

英文解释

(Aromatase) (estrogen synthetase) catalyzes the demethylation of androgens' carbon 19, producing phenolic 18-carbon estrogens. Aromatase is most widely known for its roles in reproduction and reproductive system diseases, and as a target for inhibitor therapy in estrogen-sensitive diseases including cancer, endometriosis, and leiomyoma.

中文解释

芳香化酶 (雌激素合成酶) 催化雄激素的 19 位碳去甲基化，产生酚类 18 位碳雌激素。 芳香化酶因其在生殖和生殖系统疾病中的作用而广为人知，并作为雌激素敏感疾病（包括癌症、子宫内膜异位症和平滑肌瘤）的抑制剂治疗靶点。

参考文献

[1]. Jennifer Blakemore, et al. Aromatase: Contributions to Physiology and Disease in Women and Men. Physiology (Bethesda). 2016 Jul;31(4):258-69.