Cancer-associated fibroblasts (CAFs)

癌症相关成纤维细胞

英文解释

Cancer-associated fibroblasts (CAFs) are a key component of the tumour microenvironment with diverse functions, including matrix deposition and remodelling, extensive reciprocal signalling interactions with cancer cells and crosstalk with infiltrating leukocytes.

中文解释

癌症相关成纤维细胞 (CAF) 是肿瘤微环境的关键组成部分，具有多种功能，包括基质沉积和重塑、与癌细胞的广泛相互信号作用以及与浸润白细胞的相互作用。

参考文献

[1]. Sahai E, et al. A framework for advancing our understanding of cancer-associated fibroblasts. Nat Rev Cancer. 2020 Mar;20(3):174-186.