Cannabinoid receptor 2 (CB2)

大麻素受体2

英文解释

Cannabinoid receptor 2 (CB2) is predominately expressed in the immune system, and selective modulation of CB2 without the psychoactivity of CB1 has therapeutic potential in inflammatory, fibrotic, and neurodegenerative diseases. CB2 has a high degree of homology and shares 44% sequence identity with CB1.

中文解释

大麻素受体 2 (CB2) 主要在免疫系统中表达，在没有 CB1 活性的情况下选择性调节 CB2 在炎症、纤维化和神经退行性疾病中具有治疗潜力。CB2 具有高度同源性，与 CB1 具有 44% 的序列同一性。

参考文献

[1]. Xiaoting Li, et al. Crystal Structure of the Human Cannabinoid Receptor CB2. Cell. 2019 Jan 24;176(3):459-467.e13.