Casein kinase 1 (CSNK1) family

丝氨酸/苏氨酸激酶的酪蛋白激酶 1

英文解释

The casein kinase 1 (Csnk1) family of serine/threonine kinases regulates dopamine receptor (DR) signaling, leading to inhibition of protein phosphatase 1 and a shift in the phosphorylation state of many downstream proteins. By modulating DR-activated phosphorylation cascades, Csnk1 plays a central role in neuropsychiatric disorders.

中文解释

丝氨酸/苏氨酸激酶的酪蛋白激酶 1 (Csnk1) 家族调节多巴胺受体 (DR) 信号，导致蛋白磷酸酶 1 的抑制和许多下游蛋白质磷酸化状态的转变。通过调节 DR 激活的磷酸化级联，Csnk1 在神经精神疾病中起着核心作用。

参考文献

[1]. Yinglin Huang, et al. Association between a casein kinase 1 ε gene polymorphism and schizophrenia in a Chinese Han population. J Mol Neurosci. 2012 Jul;47(3):470-4.