Catalytic core domain (CCD)

催化核心域

英文解释

Catalytic core domain (CCD)is aspecific region of an enzyme molecule that can directly bind to and catalyze a chemical reaction of a substrate. For enzymes that do not require cofactors, it consists of several or even a dozen amino acid residues that are far apart in primary structure but close to each other in tertiary structure; For enzymes that require cofactors, the cofactor or some part of its structure is often a component of the active site.

中文解释

催化核心域 (CCD) 是酶分子中能直接结合并催化底物化学反应的特定区域。对于不需辅因子的酶来说，它包括几个甚至十几个氨基酸残基，这些残基一级结构相距甚远，但三级结构上相互靠近；对于需辅因子的酶来说，辅因子或者其某一部分结构，往往就是活性部位的组成部分。

参考文献

[1]. Zhang G, et al. Structure of the adenylyl cyclase catalytic core. Nature. 1997 Mar 20;386(6622):247-53.