Live kinase B1 (LKB1)

激酶 B1

英文解释

Live kinase B1 (LKB1) is a tumor suppressor. LKB1 encodes serine-threonine kinase (STK) 11 that activates AMP-activated protein kinase (AMPK) and its 13 superfamily members, regulating multiple biological processes, such as cell polarity, cell cycle arrest, embryo development, apoptosis, and bioenergetics metabolism.

中文解释

激酶 B1 (LKB1) 是一种肿瘤抑制因子。LKB1 编码丝氨酸苏氨酸激酶 (STK) 11，激活 AMP 活化蛋白激酶 (AMPK) 及其 13 个超家族成员，调控细胞极性、细胞周期阻滞、胚胎发育、凋亡和生物能量代谢等多种生物过程。

参考文献

[1]. Yanghe Zhang, et al. LKB1 deficiency-induced metabolic reprogramming in tumorigenesis and non-neoplastic diseases. Mol Metab. 2021 Feb;44:101131.