Nicotinamide adenine dinucleotide (NAD)

烟酰胺腺嘌呤二核苷酸

英文解释

Nicotinamide adenine dinucleotide (NAD) is an abundant cofactor. NAD acts as a cosubstrate for several enzymes, such as sirtuins, PARPs and some ectoenzymes like CD38. NAD regulates critical biological processes like gene expression, DNA repair, calcium signalling and circadian rhythms.

中文解释

烟酰胺腺嘌呤二核苷酸 (NAD) 是一种含量丰富的辅因子。NAD 可作为几种酶的共底物，例如去乙酰化酶、PARP 和一些胞外酶，如 CD38。 NAD 调节关键的生物过程，如基因表达、DNA 修复、钙信号和昼夜节律。

参考文献

[1]. Tannous C, et al. Nicotinamide adenine dinucleotide: Biosynthesis, consumption and therapeutic role in cardiac diseases. Acta Physiol (Oxf). 2021 Mar;231(3):e13551.