NOD-like receptors (NLRs)

NOD 样受体

英文解释

NOD-like receptors (NLRs) are highly conserved cytosolic pattern recognition receptors. NLRs plays a critical function in surveying the intracellular environment for the presence of infection, noxious substances, and metabolic perturbations. NLRs are sub-divided into four subfamilies based on the variation in their N-terminal domain: NLRA or Class II transactivator (CIITA), NLRBs or neuronal apoptosis inhibitor proteins (NAIPs).

中文解释

NOD 样受体 (NLR) 是高度保守的胞质模式识别受体。NLR 在细胞内感染、有毒物质和代谢扰动方面起着关键作用。NLR 根据其 N 末端结构域的变化可分为四个亚家族: NLRA, II 类反式激活因子 (CIITA)、NLRB, 神经元凋亡抑制蛋白 (NAIP)。

参考文献

[1]. Zhong Y, et al. Functions of NOD-Like Receptors in Human Diseases. Front Immunol. 2013 Oct 16;4:333.