Receptor protein tyrosine kinase (rPTK)

受体蛋白酪氨酸激酶

英文解释

Receptor protein tyrosine kinases (RPTK) is a ransmembrane (TM) protein, monitoring a cell s extracellular environment and produce internal cellular responses to external cues. RPTK consists an extracellular ligand binding domain, a hydrophobic TM domain and a cytoplasmic kinase domain. RPTK signal transduction is initiated when a polypeptide ligand binds to the extracellular domain of the receptor. Ligand binding induces receptor oligomerization resulting in autophosphorylation of the cytoplasmic portion of the receptor. Ultimately, interaction of activated RPTK with cytoplasmic proteins leads to changes in metabolism and gene transcription. RPTK play crucial roles in cell-growth regulation, differentiation and development of metazoan organisms.

中文解释

受体蛋白酪氨酸激酶 (RPTK) 是一种跨膜 (TM) 蛋白，可监测细胞的细胞外环境并对外部信号产生内部细胞反应。RPTK 由一个胞外配体结合结构域、一个疏水性 TM 结构域和一个胞质激酶结构域组成。 当多肽配体与受体的细胞外结构域结合时，启动 RPTK 信号转导。配体结合诱导受体寡聚化，导致受体细胞质部分的自磷酸化。 最终，活化的 RPTK 与细胞质蛋白的相互作用导致新陈代谢和基因转录的变化。RPTK 在后生动物的细胞生长调节、分化和发育中发挥着至关重要的作用。

参考文献

[1]. D A Siever, et al. Identification of a complete Cek7 receptor protein tyrosine kinase coding sequence and cDNAs of alternatively spliced transcripts. Gene. 1994 Oct 21;148(2):219-26.