Receptor tyrosine kinase (RTK)

受体酪氨酸激酶

英文解释

Receptor tyrosine kinases (RTKs) are single-span transmembrane receptors in which relatively conserved intracellular kinase domains are coupled to divergent extracellular modules to initiate receptor signaling. RTKs play communication effect between cells and with their extracellular environment, contributing to the maintenance of adult organismal homeostasis.

中文解释

受体酪氨酸激酶 (RTK) 是单跨度跨膜受体，其中相对保守的细胞内激酶结构域与不同的细胞外模块偶联以启动受体信号传导。RTKs 发挥细胞间及其与细胞外环境的通讯作用，有助于维持成体机体稳态。

参考文献

[1]. Raphael Trenker, et al. Receptor tyrosine kinase activation: From the ligand perspective. Curr Opin Cell Biol. 2020 Apr;63:174-185.