Receptor-Interacting Protein 1 (RIP1)

受体相互作用蛋白 1

英文解释

Receptor-interacting protein 1 (RIP1) is the key signaling molecule of Death receptors (DRs)-initiated intracellular pathway. RIP1 is also an important regulator of endogenous anti-oxidants and ROS scavenging enzymes. RIP1 may be involved in neoplastic, autoimmune, neurodegenerative, inflammatory, and metabolic diseases.

中文解释

受体相互作用蛋白 1 (RIP1) 是死亡受体 Death receptors (DRs) 启动的细胞内通路的关键信号分子。RIP1 还是内源性抗氧化剂和 ROS 清除酶的重要调节因子。RIP1 可能参与肿瘤、自身免疫、神经退行性、炎症和代谢疾病。

参考文献

[1]. Vladislav Temkin, et al. From death receptor to reactive oxygen species and c-Jun N-terminal protein kinase: the receptor-interacting protein 1 odyssey. Immunol Rev. 2007 Dec;220:8-21.