Receptor-interacting protein kinase 1 (RIPK1)

受体相互作用蛋白激酶 1

英文解释

Receptor-interacting protein kinase 1 (RIPK1) regulates the cellular decision between pro-survival NF-κB signalling and death. RIPK1 is a key mediator of cell death and inflammation. The activation of RIPK1 kinase is related to autoimmune and neurodegenerative conditions.

中文解释

受体相互作用蛋白激酶 1 (RIPK1) 调节 NF-κB 信号转导和死亡之间的平衡， 是细胞死亡和炎症的关键介质。RIPK1 激酶的激活与自身免疫和神经退行性疾病有关。

参考文献

[1]. Mifflin L, et al. Receptor-interacting protein kinase 1 (RIPK1) as a therapeutic target. Nat Rev Drug Discov. 2020 Aug;19(8):553-571.