Renal fibrosis

肾纤维化

英文解释

Renal fibrosis is characterized by excessive deposition of extracellular matrix (ECM) that disrupts and replaces functional parenchyma, which leads to organ failure. It is known as the major pathological mechanism of chronic kidney disease (CKD).

中文解释

肾纤维化 (ECM) 的特征是细胞外基质的过度沉积，破坏和取代功能实质，导致器官衰竭。它被认为是慢性肾脏疾病 (CKD) 的主要病理机制。

参考文献

[1]. Ma TT, Meng XM. TGF-β/Smad and Renal Fibrosis. Adv Exp Med Biol. 2019;1165:347-364.