The Bromodomain and Extra-Terminal (BET) family of proteins

溴结构域和末端外

英文解释

The Bromodomain and Extra-Terminal (BET) family of proteins is characterized by the presence of two tandem bromodomains and an extra-terminal domain.The mammalian BET family of proteins comprises BRD2, BRD3, BRD4, and BRDT, which are encoded by paralogous genes.BET proteins play a crucial role in regulating gene transcription through epigenetic interactions between bromodomains and acetylated histones during cellular proliferation and differentiation processes.

中文解释

溴结构域和末端外 (BET) 蛋白家族的特点是存在两个串联的溴结构域和一个末端外结构域。哺乳动物 BET 蛋白家族包括由旁系同源基因编码的 BRD2、BRD3、BRD4 和 BRDT。BET 蛋白在细胞增殖和分化过程中通过溴结构域和乙酰化组蛋白之间的表观遗传相互作用在调节基因转录方面发挥着至关重要的作用。

参考文献

[1]. Yasushi Taniguchi, et al. The Bromodomain and Extra-Terminal Domain (BET) Family: Functional Anatomy of BET Paralogous Proteins. Int J Mol Sci. 2016 Nov 7;17(11):1849.