The bromodomain and extraterminal (BET) family

溴域和外域家族

英文解释

The bromodomain and extraterminal domain (BET) family are important transcription regulators. The BET family of proteins consists of four conserved mammalian members (BRD2, BRD3, BRD4, and BRDT) that regulate the expression of many immunity-associated genes and pathways.

中文解释

溴域和外域(BET)家族是重要的转录调控因子。BET蛋白家族由四个保守的哺乳动物成员(BRD2, BRD3, BRD4和BRDT)组成，它们调节许多免疫相关基因和通路的表达。

参考文献

[1]. Nian Wang, et al. The BET family in immunity and disease. Signal Transduct Target Ther. 2021 Jan 19;6(1):23.
[2]. Filippo Spriano, et al. Targeting BET bromodomain proteins in cancer: The example of lymphomas. Pharmacol Ther. 2020 Nov;215:107631.