The human breast cancer resistance protein (BCRP/ABCG2)

人乳腺癌抗性蛋白

英文解释

The human breast cancer resistance protein (BCRP/ABCG2), the second member of the G subfamily of the large The ATP-binding cassette (ABC) transporter superfamily, is an ATP-binding cassette (ABC) efflux transporter. BCRP was initially discovered in multidrug resistant breast cancer cell lines.

中文解释

人乳腺癌抗性蛋白 (BCRP/ABCG2) 是大 ATP 结合盒 (ABC) 转运蛋白超家族 G 亚家族的第二个成员，是一种 ATP 结合盒 外排转运蛋白。BCRP 最初是在多重耐药乳腺癌细胞系中发现的。

参考文献

[1]. Zhanglin Ni, et al. Structure and function of the human breast cancer resistance protein (BCRP/ABCG2). Curr Drug Metab. 2010 Sep;11(7):603-17.
[2]. Qingcheng Mao, et al. Role of the breast cancer resistance protein (BCRP/ABCG2) in drug transport--an update. AAPS J. 2015 Jan;17(1):65-82.