The receptor for advanced glycation end products (RAGE)

晚期糖基化终产物受体

英文解释

The receptor for advanced glycation end products (RAGE) is a single-transmembrane and multi-ligand pattern recognition receptor of the immunoglobulin protein super family. RAGE is expressed at low levels under normal physiology, but it is highly upregulated under chronic inflammation because of the accumulation of various RAGE ligands. RAGE also is expressed by multiple cell types in the brain and spinal cord that are linked to the pathogenesis of neurovascular and Neurodegenerative diseases (NDDs). RAGE has effect on numerous intracellular signalling mechanisms.

中文解释

晚期糖基化终产物受体（RAGE）是免疫球蛋白超家族的单跨膜多配体模式识别受体。RAGE 在正常生理条件下以低水平表达，但在慢性炎症下由于各种 RAGE 配体的积累而高度上调。RAGE 还由大脑和脊髓中的多种细胞类型表达，这些细胞类型与神经血管和神经退行性疾病 神经退行性疾病 的发病机制有关。RAGE 对许多细胞内信号传导机制有影响。

参考文献

[1]. Uzma Shahab, et al. The receptor for advanced glycation end products: A fuel to pancreatic cancer. Semin Cancer Biol. 2018 Apr;49:37-43.
[2]. Barry I Hudson, et al. Targeting RAGE Signaling in Inflammatory Disease. Annu Rev Med. 2018 Jan 29;69:349-364.
[3]. Michael MacLean, et al. The Receptor for Advanced Glycation End Products (RAGE) and DIAPH1: Implications for vascular and neuroinflammatory dysfunction in disorders of the central nervous system. Neurochem Int. 2019 Jun;126:154-164.