Thymidylate synthase (TS)

胸苷酸合酶

英文解释

Thymidylate synthase (TS) is a key enzyme in the de novo synthesis of 2V-deoxythymidine-5V-monophosphate (dTMP). TS catalyzes the methylation of 2V-deoxyuridine5V-monophosphate (dUMP) to dTMP for which 5,10-methylene-tetrahydrofolate (CH2-THF) is the methyl donor. TS is an important target for chemotherapy.

中文解释

胸苷酸合酶 (TS) 是 2V-脱氧胸苷-5V-单磷酸 (dTMP) 从头合成的关键酶。TS 催化 2V-脱氧尿苷5V-单磷酸 (dUMP) 甲基化为 dTMP，其中 5,10-亚甲基-四氢叶酸 (CH2-THF) 是甲基供体。TS 是化学疗法的重要靶标。

参考文献

[1]. G J Peters, et al. Induction of thymidylate synthase as a 5-fluorouracil resistance mechanism. Biochim Biophys Acta. 2002 Jul 18;1587(2-3):194-205.