TNF super family

肿瘤坏死因子超家族

英文解释

Tumor necrosis factor superfamily is a superfamily of type II transmembrane proteins, mainly expressed by immune cells, containing TNF homologous domains and forming trimers. TNF is released from the cell membrane by extracellular proteolytic lysis and functions as a cytokine. The TNF superfamily regulates a variety of cellular functions, including immune response and inflammation, as well as proliferation, differentiation, apoptosis, and embryogenesis.

中文解释

肿瘤坏死因子超家族是II型跨膜蛋白的超家族，主要由免疫细胞表达，包含TNF同源结构域并形成三聚体。肿瘤坏死因子由胞外蛋白水解裂解从细胞膜中释放出来，并作为细胞因子发挥作用。肿瘤坏死因子超家族调节多种细胞功能，包括免疫反应和炎症，也包括增殖、分化、凋亡和胚胎发生。

参考文献

[1]. Flavell RA. The relationship of inflammation and initiation of autoimmune disease: role of TNF super family members. Curr Top Microbiol Immunol. 2002;266:1-9.