Tumor necrosis factor receptor superfamily (TNFSF/TNFRSF)

TNFR 受体超家族

英文解释

The tumor necrosis factor (TNF) and TNF receptor superfamilies (TNFSF/TNFRSF) include 19 ligands and 29 receptors. Interactions among these TNFSF ligands and TNFRSF receptors mediate signaling that controls the survival, proliferation, differentiation, and effector functions of both immune and non-immune cells.

中文解释

肿瘤坏死因子 (TNF) 和 TNFR 受体超家族 (TNFSF/TNFRSF) 包括 19 种配体和 29 种受体。这些 TNFSF 配体和 TNFRSF 受体之间的相互作用介导控制两者存活、增殖、分化和效应功能的信号免疫细胞和非免疫细胞。

参考文献

[1]. Catherine Dostert, et al. The TNF Family of Ligands and Receptors: Communication Modules in the Immune System and Beyond. Physiol Rev. 2019 Jan 1;99(1):115-160.