Tumor necrosis factor-α (TNF-α)

肿瘤坏死因子-α

英文解释

Tumor necrosis factor-α (TNF-α)is a pro-inflammatory cytokine. TNF-α has multi-biological effects by binding to p55 receptor and p75 receptor, such as causing inflammation, apoptotic cell death, and mediate the release of variety cytokines like IL-6, IL-8 and IL-1β.

中文解释

肿瘤坏死因子-α (TNF-α) 是一种促炎细胞因子。TNF-α 通过与 p55 受体和 p75 受体结合而发挥多种生物学作用，如引起炎症、凋亡细胞死亡，并介导 IL-6、IL-8 和 IL-1β 等多种细胞因子的释放。

参考文献

[1]. Ma K, Zhang H, Baloch Z. Pathogenetic and Therapeutic Applications of Tumor Necrosis Factor-α (TNF-α) in Major Depressive Disorder: A Systematic Review. Int J Mol Sci. 2016 May 14;17(5):733.