Tumornecrosisfactor receptor-related factors (TRAFs)

肿瘤坏死因子受体相关因子

英文解释

Tumor necrosis factor receptor-related factors (TRAFs) are important linker molecules in the tumor necrosis factor superfamily (TNFSF) and the Toll-like/interleukin-1 receptor (TLR/ILR) superfamily. There are seven members: TRAF1-TRAF7, among those members, tumor necrosis factor receptor-associated factor 6 (TRAF6) is upregulated in various tumors, which has been related to tumorigenesis and development.

中文解释

肿瘤坏死因子受体相关因子 (TRAF) 是肿瘤坏死因子超家族 (TNFSF) 和 Toll 样/白细胞介素 1 受体 (TLR/ILR) 超家族中的重要连接分子。 共有7个成员：TRAF1-TRAF7，其中肿瘤坏死因子受体相关因子6（TRAF6）在多种肿瘤中表达上调，与肿瘤的发生发展有关。

参考文献

[1]. Jiaoduan Li, et al. The relationship between TRAF6 and tumors. Cancer Cell Int. 2020 Sep 3;20:429.