von Willebrand factor (vWF)

血管性血友病因子

英文解释

Von Willebrand factor (VWF) is a large multimeric glycoprotein produced in endothelial cells and megakaryocytes and present in subendothelial matrix, blood plasma and platelets. VWF mediates adhesion and aggregation of platelets at sites of vascular injury, which are critical for both haemostasis and thrombosis.

中文解释

血管性血友病因子 (VWF) 是一种产生于内皮细胞和巨核细胞的大型多聚糖蛋白，存在于内皮下基质、血浆和血小板中。VWF 介导血小板在血管损伤部位的粘附和聚集，这对止血和血栓形成都至关重要。

参考文献

[1]. Zaverio M Ruggeri, et al. The role of von Willebrand factor in thrombus formation. Thromb Res. 2007;120 Suppl 1(Suppl 1):S5-9.