WD repeat domain 5 (WDR5)

WD 重复域 5

英文解释

WD repeat domain 5 (WDR5) is a member of the WD40-repeat protein family that plays a critical role in multiple chromatin-centric processes. Overexpression of WDR5 correlates with a poor clinical outcome in many human cancers.

中文解释

WD 重复域 5 (WDR5) 是 WD40 重复蛋白家族的成员，在多个以染色质为中心的过程中起关键作用。WDR5 的过度表达与许多人类癌症的不良临床结果相关。

参考文献

[1]. Jianhua Tian, et al. Discovery and Structure-Based Optimization of Potent and Selective WD Repeat Domain 5 (WDR5) Inhibitors Containing a Dihydroisoquinolinone Bicyclic Core. J Med Chem. 2020 Jan 23;63(2):656-675. doi: 10.1021/acs.jmedchem.9b01608. Epub 2020 Jan 7.