WD repeat-containing protein 5 (WDR5)

WD 重复蛋白 5

英文解释

WD repeat-containing protein 5 (WDR5) is a member of the WD40 protein family. WDR5 is involved in gene expression regulation as an epigenetic “reader”. WDR5 interacts and recognizes the methylated fourth lysine and second arginine of histone H3, histone 3 lysine 4 (H3K4) and histone 3 arginine 2 (H3R2).

中文解释

WD 重复蛋白 5 (WDR5) 是 WD40 蛋白家族的成员。WDR5 作为表观遗传 “读者” 参与基因表达调控。 WDR5 识别并作用于组蛋白 H3、组蛋白 3 赖氨酸 4 (H3K4) 和组蛋白 3 精氨酸 2 (H3R2) 的甲基化第四个赖氨酸和第二个精氨酸。

参考文献

[1]. Chen X, et al. Targeting WD Repeat-Containing Protein 5 (WDR5): A Medicinal Chemistry Perspective. J Med Chem. 2021 Aug 12;64(15):10537-10556.