β-site APP cleaving enzyme 1 (BACE1)

β 位点 APP 裂解酶

英文解释

β-Site APP-cleaving enzyme (BACE1) can cleave the amyloid precursor protein (APP) at the β-secretase site to initiate the production of Aβ peptides, which form toxic oligomers and the amyloid plaques associated with Alzheimer's disease (AD).

中文解释

β 位点 APP 裂解酶 (BACE1) 可以在 β 分泌酶位点裂解淀粉样蛋白前体蛋白 (APP) 以启动Aβ 肽的产生，这些 Aβ 肽可形成有毒的低聚物和与阿尔茨海默病 (Alzheimer's disease (AD)) 相关的淀粉样斑块。

参考文献

[1]. Tan J, et al. Β-site APP-cleaving enzyme 1 trafficking and Alzheimer's disease pathogenesis. J Neurochem. 2012 Mar;120(6):869-80.