Tegoprazan

A proton pump inhibitor

此产品仅用于科学研究，我们不为任何个人用途提供产品和服务

库存: 现货

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促销价

数量
5mg

￥2400.00

1920.00

- +
10mg

￥3662.00

2930.00

- +
25mg

￥7337.00

5870.00

- +
50mg

￥11875.00

9500.00

- +
100mg

￥17625.00

14100.00

- +

已选 0 种 0 瓶

金额: ￥0.00

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Background

Tegoprazan is a proton pump inhibitor that inhibits H⁺/K⁺-ATPase activity in porcine gastric membrane vesicles (IC₅₀ = 0.53 ?M).¹ It completely inhibits basal gastric acid secretion in pylorus-ligated rats when administered at a dose of 10 mg/kg and reduces esophageal mucosal tissue levels of myeloperoxidase (MPO), a marker of tissue damage, in a rat model of reflux esophagitis (ED₅₀ = 5.9 mg/kg). Tegoprazan reduces ulcer area in rat models of gastric ulcers induced by naproxen, water-immersion restraint stress (WIRS), or ethanol (ED₅₀s = 0.1, 0.1, and 1.4 mg/kg, respectively).

1.Kim, D.K., Lee, K.-H., Kim, S.-J., et al.Effects of tegoprazan, a novel potassium-competitive acid blocker, on rat models of gastric acid-related diseaseJ. Pharmacol. Exp. Ther.369(3)318-327(2019)