NVS-ZP7-4

A ZIP7 inhibitor

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库存: 现货

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促销价

数量
5mg

￥1262.00

1010.00

- +
10mg

￥2450.00

1960.00

- +
25mg

￥4862.00

3890.00

- +
50mg

￥7725.00

6180.00

- +
100mg

￥12462.00

9970.00

- +

已选 0 种 0 瓶

金额: ￥0.00

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货号: ajcx13372
CAS: 2349367-89-9
别名:
分子式: C28H28FN5OS
分子量: 501.62
纯度: >98%
溶解度: DMSO : ≥ 125 mg/mL (249.19 mM);Water : < 0.1 mg/mL (insoluble)
储存: -20°C, protect from light
库存: 现货

Background

NVS-ZP7-4 is an inhibitor of the zinc transporter SLC39A7 (ZIP7).¹ It induces apoptosis in TALL-1 human T cell acute lymphoblastic leukemia cells, an effect that can be reduced by expression of the ZIP7 point mutant ZIP7^V430E. NVS-ZP7-4 (20 ?M) increases endoplasmic reticulum, but not cytosolic, zinc levels in U2OS cells. It inhibits ferroptosis induced by erastin in MDA-MB-231 and RCC4 cells when used at a concentration of 10 ?M.²

1.Nolin, E., Gans, S., Llamas, L., et al.Discovery of a ZIP7 inhibitor from a Notch pathway screenNat. Chem. Biol.15(2)179-188(2019) 2.Chen, P.-H., Wu, J., Xu, Y., et al.Zinc transporter ZIP7 is a novel determinant of ferroptosisCell Death Dis.12(2)198(2021)