GPI-1046

GPI-1046 是一种不含抗生素作用的免疫亲和素配体，通过上调 PFC 和 NAc 核心中的谷氨酸转运蛋白1 (GLT1) 来减少乙醇摄入。GPI-1046 是 FK506 的类似物，在神经退行性疾病模型中显示出神经保护作用。GPI-1046 易穿过血脑屏障并促进中枢神经系统中多巴胺 (DA) 细胞的再生，这与啮齿动物模型中的功能恢复相关。

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库存: 现货

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数量
1mg

￥650.00

520.00

- +
5mg

￥1962.00

1570.00

- +
10mg

￥3262.00

2610.00

- +
50mg

￥0.00

0.00

- +
100mg

￥0.00

0.00

- +

已选 0 种 0 瓶

金额: ￥0.00

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货号: ajcx15360
CAS: 186452-09-5
别名: 1-(1,2-二氧代-3,3-二甲基戊基)-L脯氨酸-(3-吡啶基)-丙酯
分子式: C20H28N2O4
分子量: 360.45
纯度: >98%
溶解度: DMSO: ≥ 100 mg/mL (277.43 mM)
储存: 4°C, protect from light
库存: 现货

Background

GPI-1046 is a immunophilin ligand without antibiotic action and attenuates ethanol intake in part through the upregulation of glutamate transporter 1 (GLT1) in PFC and NAc-core. GPI-1046 is an analog of FK506, which is an immunophilin ligand that has been shown neuroprotective effects in neurodegenerative disease models[1]. GPI-1046 readily crosses the blood-brain barrier and promotes the regeneration of dopamine (DA) cells in the CNS in association with functional recovery in rodent models[2].

[1]. Sari Y, et al. Neuroimmunophilin GPI-1046 reduces ethanol consumption in part through activation of GLT1 in alcohol-preferring rats. Neuroscience. 2012 Dec 27;227:327-35. [2]. Eberling JL, et al. The immunophilin ligand GPI-1046 does not have neuroregenerative effects in MPTP-treated monkeys. Exp Neurol. 2002 Dec;178(2):236-42.