Background
NDI-091143 is an allosteric inhibitor of ATP citrate lyase (ACL; Ki = 7 nM).1 It inhibits the production of ADP in a cell-free assay and oxaloacetate production in an enzyme-coupled assay (IC50s = 2.1 and 4.8 nM, respectively).
1.Wei, J., Leit, S., Kuai, J., et al.An allosteric mechanism for potent inhibition of human ATP-citrate lyaseNature568(7753)566-570(2019)
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