Isobergapten

A furanocoumarin with diverse biological activities.

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库存: 现货

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5mg

￥2550.00

2040.00

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10mg

￥4312.00

3450.00

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Background

Isobergapten is a furanocoumarin that has been found in H. persicum and has diverse biological activities.^1,2,3 It inhibits α-glucosidase and scavenges DPPH radicals in cell-free assays (IC₅₀s = 0.385 and 28.6 ?M, respectively).¹ Isobergapten is active against S. aureus, B. cereus, P. aeruginosa, and S. entritidis (MICs = 125 ?g/ml for all).² It reduces tumor growth in a B16/F10 murine melanoma model when administered at a dose of 0.5 mg/kg in combination with ultraviolet A (UVA) radiation.³

1.Dehghan, H., Sarrafi, Y., Salehi, P., et al.α-Glucosidase inhibitory and antioxidant activity of furanocoumarins from Heracleum persicumMed. Chem. Res.26849-855(2017) 2.Dehghan, H., Rezaee, P., and Aliahmadi, A.Bioassay screening of 12 Iranian plants and detection of antibacterial compounds from Heracleum persicum using a TLC bioautography methodJ. Liq. Chromatogr. R. T.43381-387(2020) 3.Sumiyoshi, M., Sakanaka, M., Taniguchi, M., et al.Anti-tumor effects of various furocoumarins isolated from the roots, seeds and fruits of Angelica and Cnidium species under ultraviolet A irradiationJ. Nat. Med.68(1)83-94(2014)