(+)-AS 115

Single enantiomer of a potent inhibitor of a cancer-promoting enzyme

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库存: 现货

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数量
100ug

￥975.00

780.00

- +
500ug

￥4350.00

3480.00

- +
1mg

￥7725.00

6180.00

- +

已选 0 种 0 瓶

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货号: ajcx19120
CAS: N/A
别名:
分子式: C21H32FNO4
分子量: 381.5
纯度: >98%
溶解度: DMF: 12 mg/ml,DMSO: 12 mg/ml,Ethanol: 30 mg/ml,Ethanol:PBS (pH 7.2) (1:3): 0.25 mg/ml
储存: Store at -20°C
库存: 现货

Background

KIAA1363 is a 2-acetyl monoacylglyceryl ether (MAGE) hydrolase that is upregulated in aggressive cancers from various tissues. The enzyme catalyzes the hydrolysis of the 2-acetyl MAGE to MAGE and serves as a central enzyme in the PAF and LPA signaling network. AS 115 is a potent and selective inactivator of KIAA1363, displaying an IC50 value of 150 nM when tested as a racemic mixture in the invasive ovarian cancer cell line SKOV3. Treatment of SKOV3 cells with 10 µM AS-115 for 4 hours significantly reduced the formation of MAGE, alkyl-lysophosphatidylcholine, and alkyl-lysophosphatidic acid. The activity of the individual enantiomers of AS 115, i.e., (+)-AS 115 and (-)-AS 115, has not been determined.