ML-396

A positive allosteric modulator of group III mGluRs

此产品仅用于科学研究，我们不为任何个人用途提供产品和服务

库存: 现货

可选规格

包装

价格

促销价

数量
1mg

￥512.00

410.00

- +
5mg

￥1812.00

1450.00

- +
10mg

￥3375.00

2700.00

- +
25mg

￥7062.00

5650.00

- +

已选 0 种 0 瓶

金额: ￥0.00

首页收藏

货号: ajcx20668
CAS: 1630936-95-6
别名: ML396
分子式: C17H11Cl2N3O2
分子量: 360.2
纯度: >98%
溶解度: Chloroform: slightly soluble,DMSO: slightly soluble
储存: Store at -20°C
库存: 现货

Background

ML-396 is a positive allosteric modulator of group III metabotropic glutamate receptors (mGluRs) with EC50 values of 108, 146, and 128 nM for mGluR4, mGluR7, and mGluR8, respectively, in calcium mobilization assays.1 ML-396 potentiates LSP4-2022-induced reductions in paired-pulse field excitatory post synaptic potential (fEPSP) slopes in mouse hippocampal slices. In vivo, ML-396 (30 mg/kg) restores hippocampal long-term potentiation, improves novel object recognition, contextual fear learning, and social memory, and decreases sleep apneas in the Mecp2-/- mouse model of Rett syndrome.2

|1. Jalan-Sakrikar, N., Field, J.R., Klar, R., et al. Identification of positive allosteric modulators VU0155094 (ML397) and VU0422288 (ML396) reveals new insights into the biology of metabotropic glutamate receptor 7. ACS Chem. Neurosci. 5(12), 1221-1237 (2014).|2. Gogliotti, R.G., Senter, R.K., Fisher, N.M., et al. mGlu7 potentiation rescues cognitive, social, and respiratory phenotypes in a mouse model of Rett syndrome. Sci. Transl. Med. 9(403), (2017).