(±)12(13)-EpOME-d4

A neuropeptide with diverse biological activities

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库存: 现货

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25ug

￥1862.00

1490.00

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50ug

￥3550.00

2840.00

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100ug

￥6650.00

5320.00

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250ug

￥14637.00

11710.00

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货号: ajcx20828
CAS: N/A
别名: (±)12,13-EODE-d4, Isoleukotoxin-d4, (±)Vernolic Acidd4
分子式: C18H28D4O3
分子量: 300.5
纯度: >98%
溶解度: DMF: 50 mg/ml,DMSO: 50 mg/ml,Ethanol: 50 mg/ml,PBS (pH 7.2): 1 mg/ml
储存: Store at -20°C
库存: 现货

Background

(±)12(13)-EpOME-d4 is intended for use as an internal standard for the quantification of (±)12(13)-EpOME by GC- or LC-MS. (±)12(13)-EpOME is the 12,13-cis epoxide form of linoleic acid .^1,2 It is formed primarily via linoleic acid metabolism by the cytochrome P450 (CYP) isoforms CYP2J2, CYP2C8, and CYP2C9, however, CYP1A1 can contribute to (±)12(13)-EpOME production when pharmacologically induced.² (±)12(13)-EpOME (500 µM) induces mitochondrial dysfunction and cell death in renal proximal tubule epithelial cells.

1.Hayakawa, M., Sugiyama, S., Takamura, T., et al.Neutrophils biosynthesize leukotoxin, 9,10-epoxy-12-octadecenoateBiochem. Biophys. Res. Commun.137(1)424-430(1986) 2.Hildreth, K., Kodani, S.D., Hammock, B.D., et al.Cytochrome P450-derived linoleic acid metabolites EpOMEs and DiHOMEs: A review of recent studiesJ. Nutr. Biochem.19108484(2020)