1-Stearoyl-2-Arachidonoyl-d8-sn-glycero-3-PC

An internal standard for the quantification of 1-stearoyl-2-arachidonoyl-sn-glycero-3-PC

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库存: 现货

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50ug

￥887.00

710.00

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100ug

￥1687.00

1350.00

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500ug

￥7062.00

5650.00

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1mg

￥12237.00

9790.00

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货号: ajcx21196
CAS: 161922-50-5
别名: 18:0/20:4-d8-PC, PC(18:0/20:4-d8), SAPCd8, 1-Stearoyl-2-Arachidonoyl-d8-sn-glycero-3-Phosphatidylcholine, 1-Stearoyl-2-Arachidonoyl-d8-sn-glycero-3-Phosphocholine
分子式: C46H76D8NO8P
分子量: 818.2
纯度: >98%
溶解度: Ethanol: 30 mg/ml,Ethanol:PBS (pH 7.2)(1:2): 0.3 mg/ml
储存: Store at -20°C
库存: 现货

Background

1-Stearoyl-2-arachidonoyl-d₈-sn-glycero-3-PC is intended for use as an internal standard for the quantification of 1-stearoyl-2-arachidonoyl-sn-glycero-3-PC by GC- or LC-MS. 1-Stearoyl-2-arachidonoyl-sn-glycero-3-PC (SAPC) is a phospholipid containing stearic acid and arachidonic acid at the sn-1 and sn-2 positions, respectively. It is a component of LDL and has been found in human stenotic aortic valves and atherosclerotic plaques.^1,2 Levels of SAPC are increased in the subepithelial invasive region compared to the superficial region of tumor tissue samples from patients with superficial-type pharyngeal squamous cell carcinoma.³ SAPC unilamellar vesicles have been used as substrates to quantify the activity of secretory phospholipase A₂ (sPLA₂) in the presence or absence of inhibitors.⁴ SAPC has also been used in the formation of lipid bilayers to study the effects of lipid composition on bilayer phase transitions.⁵

1.Milne, G.L., Seal, J.R., Havrilla, C.M., et al.Identification and analysis of products formed from phospholipids in the free radical oxidation of human low density lipoproteinsJ. Lipid Res.46(2)307-319(2005) 2.Lehti, S., K?kel?, R., H?rkk?, S., et al.Modified lipoprotein-derived lipid particles accumulate in human stenotic aortic valvesPLoS One8(6)e65810(2013) 3.Ishikawa, S., Tateya, I., Hayasaka, T., et al.The distribution of phosphatidylcholine species in superficial-type pharyngeal carcinomaBiomed. Res. Int.5387913(2017) 4.Schebb, N.H., Falck, D., Faber, H., et al.Fast method for monitoring phospholipase A2 activity by liquid chromatography-electrospray ionization mass spectrometryJ. Chromatogr. A1216(27)5249-5255(2009) 5.Tada, K., Goto, M., Tamai, N., et al.Pressure effect on the bilayer phase transition of asymmetric lipids with an unsaturated acyl chainAnn. N.Y. Acad. Sci.1189(1)77-85(2010)