2-Amino-5-bromo-benzonitrile

A heterocyclic building block

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库存: 现货

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500mg

￥512.00

410.00

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1g

￥825.00

660.00

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货号: ajcx21248
CAS: 39263-32-6
别名: 2-氨基-5-溴苯甲腈
分子式: C7H5BrN2
分子量: 197
纯度: >98%
溶解度: DMF: 30 mg/ml,DMSO: 30 mg/ml,Ethanol: 30 mg/ml,Ethanol:PBS (pH 7.2) (1:3): 0.25 mg/ml
储存: Store at -20°C
库存: 现货

Background

2-Amino-5-bromo-benzonitrile is a heterocyclic building block.^1,2 It has been used in the synthesis of copper-ligand coordination complexes and 4-amino-3-benzimidazol-2-ylhydroquinolin-2-one-based multi-targeted receptor tyrosine kinase (RTK) inhibitors with anticancer activity.

1.Primik, M.F., G?schl, S., Jakupec, M.A., et al.Structure-activity relationships of highly cytotoxic copper(II) complexes with modified indolo[3,2-c]quinoline ligandsInorg. Chem.49(23)11084-11095(2010) 2.Renhowe, P.A., Pecchi, S., Shafer, C.M., et al.Design, structure-activity relationships and in vivo characterization of 4-amino-3-benzimidazol-2-ylhydroquinolin-2-ones: A novel class of receptor tyrosine kinase inhibitorsJ. Med. Chem.52(2)278-292(2009)