5-Butyl-4-[2,3-difluoro-4-(phenylmethoxy)phenyl]-6-phenyl-2-pyrimidinamine

An mPGES-1 inhibitor

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库存: 现货

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250ug

￥712.00

570.00

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500ug

￥1375.00

1100.00

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1mg

￥2162.00

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货号: ajcx21456
CAS: 2253745-78-5
别名:
分子式: C27H25F2N3O
分子量: 445.5
纯度: >98%
溶解度: Chloroform: 10 mg/ml,Ethanol: 10 mg/ml,Methyl Acetate: 1 mg/ml
储存: Store at -20°C
库存: 现货

Background

5-Butyl-4-[2,3-difluoro-4-(phenylmethoxy)phenyl]-6-phenyl-2-pyrimidinamine is an inhibitor of microsomal prostaglandin E synthase-1 (mPGES-1; IC₅₀s = 66 and 2,730 nM for the human and mouse enzymes, respectively).¹ It is selective for mPGES-1 over COX-1 but does inhibit COX-2 at 20 µM. It also inhibits LPS-induced prostaglandin E₂ production in mouse peritoneal cells (IC₅₀ = 12 nM). In vivo, 5-butyl-4-[2,3-difluoro-4-(phenylmethoxy)phenyl]-6-phenyl-2-pyrimidinamine (25 mg/kg) reduces carrageenan-induced paw edema in rats.

1.Kal?ic, F., Kolman, V., Ajani, H., et al.Polysubstituted pyrimidines as mPGES-1 inhibitors: Discovery of potent inhibitors of PGE2 production with strong anti-inflammatory effects in carrageenan-induced rat paw edemaChemMedChem15(15)1398-1407(2020)