Abacavir-d4

An internal standard for the quantification of abacavir

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库存: 现货

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500ug

￥1962.00

1570.00

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1mg

￥3712.00

2970.00

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货号: ajcx21574
CAS: 1260619-56-4
别名: 阿巴卡韦 d4
分子式: C14H14D4N6O
分子量: 290.4
纯度: >98%
溶解度: Acetonitrile:Methanol (1:1): soluble,DMSO: soluble
储存: Store at -20°C
库存: 现货

Background

Abacavir-d₄ is intended for use as an internal standard for the quantification of abacavir by GC- or LC-MS. Abacavir is a nucleoside analog and an inhibitor of HIV-1 reverse transcriptase (K_i = 2.1 µM for the wild-type enzyme).¹ It inhibits replication of a variety of HIV-1 and HIV-2 strains, including strains resistant to 3'-azido-3'-deoxythymidine or 2',3'-dideoxyinosine , in HeLa cells stably expressing CD4 (IC₅₀s = 5.8-21 µM). Abacavir inhibits replication of eight HIV-1 clinical isolates in phytohemagglutinin-stimulated isolated human peripheral blood lymphocytes with a mean IC₅₀ value of 0.26 µM. It inhibits hepatitis B virus (HBV) DNA synthesis in HepG2 cells (IC₅₀ = 7 µM) and is also active against human cytomegalovirus (CMV) strain AD169 and the Petaluma strain of feline immunodeficiency virus (FIV) in plaque reduction assays (IC₅₀s = 32 and 0.4 µM, respectively). Formulations containing abacavir have been used in the treatment of HIV infection.

1.Daluge, S.M., Good, S.S., Faletto, M.B., et al.1592U89, a novel carbocyclic nucleoside analog with potent, selective anti-human immunodeficiency virus activityAntimicrob. Agents Chemother.41(5)1082-1093(1997)