Busulfan-d8

An internal standard for the quantification of busulfan

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1mg

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货号: ajcx21868
CAS: 116653-28-2
别名: 白消安 d8
分子式: C6H6D8O6S2
分子量: 254.3
纯度: >98%
溶解度: DMF: 16.7 mg/ml,DMSO: 16.7 mg/ml,DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml
储存: Store at -20°C,protect from light
库存: 现货

Background

Busulfan-d₈ is intended for use as an internal standard for the quantification of busulfan by GC- or LC-MS. Busulfan is an alkyl sulfonate that acts as an alkylating antineoplastic agent.¹ It forms both intra- and interstrand crosslinks on DNA.^2,3 In mammals, busulfan causes profound and prolonged reduction in the generation of hematopoietic progenitors without significantly affecting lymphocyte levels or humoral antibody responses.⁴

1.Appelbaum, F.R.Optimizing the conditioning regimen for acute myeloid leukemiaBest Pract.Res.Clin.Haematol.22(4)543-550(2009) 2.Iwamoto, T., Hiraku, Y., Oikawa, S., et al.DNA intrastrand cross-link at the 5'-GA-3' sequence formed by busulfan and its role in the cytotoxic effectCancer Science95454-458(2004) 3.Ponti, M., Souhami, R.L., Fox, B.W., et al.DNA interstrand crosslinking and sequence selectivity of dimethanesulphonatesBritish Journal of Cancer63(5)743-747(1991) 4.Copelan, E.A., and Deeg, H.J.Conditioning for allogeneic marrow transplantation in patients with lymphohematopoietic malignancies without the use of total body irradiationBlood80(7)1648-1658(1992)