RU-SKI 201 (hydrochloride)

A neuropeptide with diverse biological activities

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库存: 现货

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数量
1mg

￥937.00

750.00

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5mg

￥4162.00

3330.00

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10mg

￥7387.00

5910.00

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货号: ajcx23446
CAS: N/A
别名:
分子式: C20H27N3OS.2HCl
分子量: 430.4
纯度: >98%
溶解度: DMF: 30 mg/ml,DMSO: 30 mg/ml,Ethanol: 30 mg/ml,Ethanol:PBS (pH 7.2) (1:3): 0.25 mg/ml
储存: Store at -20°C
库存: 现货

Background

RU-SKI 201 is an inhibitor of hedgehog acyltransferase (Hhat; IC₅₀ = 0.2 μM for recombinant enzyme).¹ It inhibits palmitoylation of sonic hedgehog (Shh) in Shh-overexpressing HEK293 cells with a tagging IC₅₀ (TC₅₀) value of 0.87 μM. RU-SKI 201 inhibits hedgehog (Hh) signaling in H520, PANC-1, and MCF-7 cancer cells co-cultured with Shh-Light2 cells (IC₅₀s = 4.8, 7.8, and 8.5 μM, respectively).

1.Rodgers, U.R., Lanyon-Hogg, T., Masumoto, N., et al.Characterization of hedgehog acyltransferase inhibitors identifies a small molecule probe for hedgehog signaling by cancer cellsACS Chem. Biol.11(12)3256-3262(2016)