4-methoxy Estrone

An active metabolite of estrone

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500ug

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货号: ajcx26068
CAS: 58562-33-7
别名: 4-甲氧基雌酮
分子式: C19H24O3
分子量: 300.4
纯度: >98%
溶解度: Chloroform: slightly soluble,Methanol: slightly soluble
储存: -20°C
库存: 现货

Background

4-methoxy Estrone is an active metabolite of the endogenous estrogen estrone .¹ It is formed from estrone by catechol-O-methyltransferase (COMT). 4-methoxy Estrone (10 and 100 nM) increases the proliferation of human umbilical vein endothelial cells (HUVECs).²

1.Dawling, S., Roodi, N., Mernaugh, R.L., et al.Catechol-O-methyltransferase (COMT)-mediated metabolism of catechol estrogens: Comparison of wild-type and variant COMT isoformsCancer Res.61(18)6716-6722(2001) 2.Lippert, C., Seeger, H., Mueck, A.O., et al.The effects of A-ring and D-ring metabolites of estradiol on the proliferation of vascular endothelial cellsLife Sci.67(13)1653-1658(2000)