GPX4 Inhibitor 26a

A GPX4 inhibitor

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库存: 现货

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促销价

数量
1mg

￥937.00

750.00

- +
5mg

￥3937.00

3150.00

- +
10mg

￥7450.00

5960.00

- +

已选 0 种 0 瓶

金额: ￥0.00

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货号: ajcx26324
CAS: N/A
别名: Glutathione Peroxidase 4 Inhibitor 26a
分子式: C29H24ClN3O3S
分子量: 530
纯度: >98%
溶解度: Chloroform: soluble
储存: -20°C
库存: 现货

Background

GPX4 inhibitor 26a is an inhibitor of glutathione peroxidase 4 (GPX4).¹ It inhibits GPX4 activity by 71.7% at 1 µM. GPX4 inhibitor 26a is cytotoxic to 4T1 and MCF-7 breast cancer cells and HT-1080 fibrosarcoma cells (IC₅₀s = 0.78, 6.9, and 0.15 µM, respectively). It decreases intracellular glutathione (GSH) levels and induces lipid peroxidation and ferroptosis in 4T1 cells when used at a concentration of 5 µM. GPX4 inhibitor 26a (15 and 30 mg/kg) reduces tumor growth in a 4T1 mouse xenograft model.

1.Tiedt, R., Degenkolbe, E., Furet, P., et al.A drug resistance screen using a selective MET inhibitor reveals a spectrum of mutations that partially overlap with activating mutations found in cancer patientsCancer Res.71(15)5255-5264(2011)