TAT-Gap19

TAT-Gap19 是一种 Cx 模拟肽，是一种特异性的连接蛋白 43 半通道 (Cx43 HC) 抑制剂。

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库存: 现货

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1mg

￥2687.00

2150.00

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Background

Cx43 hemichannel blocker (IC50 ~7 μM). No significant affinity for gap junctions or Panx1 channels. N-terminal transactivator of transcription (TAT) motif promotes membrane permeability and increases inhibitory effect of Gap19 . Active in vivo. Brain penetrant.

Abudara et al (2014) The connexin43 mimetic peptide Gap19 inhibits hemichannels without altering gap junctional communication in astrocytes. Front.Cell.Neurosci. 8 1 PMID:25374505 |Freitas-Andrade and Naus (2016) Astrocytes in neuroprotection and neurodegeneration: The role of connexin43 and pannexin1. Neuroscience. 323 207 PMID:25913636