NLRP3-IN-2

An NLRP3 inflammasome inhibitor

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货号: ajcx27812
CAS: 16673-34-0
别名: 4-[2-(5-氯-2-甲氧基苯甲酰氨基)乙基]苯磺酰胺
分子式: C16H17ClN2O4S
分子量: 368.84
纯度: >98%
溶解度: DMF: 30 mg/ml,DMSO: 30 mg/ml,DMSO:PBS (pH 7.2) (1:7): 0.14 mg/ml
储存: Store at -20°C
库存: 现货

Background

NLRP3 inflammasome inhibitor. Inhibits formation of NLRP3 inflammasome and IL-1β release in LPS and ATP-stimulated mouse macrophages and cardiomyocytes in vitro. Inhibits NLRP3 activation in mouse acute myocardial infarction and peritonitis models without affecting plasma glucose levels. Glyburide synthetic intermediate.

Marchetti et al (2014) A novel pharmacologic inhibitor of the NLRP3 inflammasome limits myocardial injury after ischemia-reperfusion in the mouse. J.Cardiovasc.Pharmacol. 63 316 PMID:24336017 |Fulp et al (2018) Structural insights of benzenesulfonamide analogues as NLRP3 inflammasome inhibitors: design, synthesis, and biological characterization. J.Med.Chem. 61 5412