Betahistine

A histamine H3 receptor antagonist and histamine H1 receptor agonist

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100mg

￥375.00

300.00

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Background

Betahistine is a histamine H₃ receptor antagonist and histamine H₁ receptor agonist.¹ In vivo, betahistine dilates pre-capillary arterioles and increases blood flow to the stria vascularis in guinea pigs.^2,3 Betahistine (8 mg/kg) reduces weight gain and increased feeding behavior induced by olanzapine in female rats.⁴ Formulations containing betahistine have been used in the treatment of balance disorders and vertigo symptoms associated with Meniere's disease.

1.Timmerman, H.Histamine agonists and antagonistsActa Otolaryngol. Suppl.4795-11(1991) 2.Bertlich, M., Ihler, F., Sharaf, K., et al.Betahistine metabolites, aminoethylpyridine, and hydroxyethylpyridine increase cochlear blood flow in guinea pigs in vivoInt. J. Audiol.53(10)753-759(2014) 3.Bertlich, M., Ihler, F., Weiss, B.G., et al.Role of capillary pericytes and precapillary arterioles in the vascular mechanism of betahistine in a guinea pig inner ear modelLife Sci.18717-21(2017) 4.Lian, J., Huang, X.-F., Pai, N., et al.Ameliorating antipsychotic-induced weight gain by betahistine: Mechanisms and clinical implicationsPharmacol. Res.10651-63(2016)